Insight into the peroxygenase activity of lytic polysaccharide monooxygenases (LPMO): Recent progress and mechanistic understanding

The discovery of lytic polysaccharide monooxygenases (LPMOs) as monocopper enzymes for the oxidative cleavage glycosidic bonds in recalcitrant polysaccharides has revolutionized our understanding enzymatic biomass conversion. In recent years, debate regarding whether LPMOs function or peroxygenases generated significant interest due to its implications mechanisms involved LPMO-mediated lignocellulosic This review provides a comprehensive analysis theoretical calculations and kinetic studies, offering detailed examination catalytic mechanism from physicochemical perspective. By reviewing investigations focused on activation O2/H2O2 impact LPMO monooxygenase/peroxygenase activity, this aims inspire novel insight innovative approaches exploring intricate LPMOs.